MRI/MRS or micro-MRI/MRS (<3T)

Magnetic resonance imaging (MRI) is an imaging technique used to image “in vivo” anatomy and physiological processes, with high spatial and temporal resolution. MRI scanners use strong magnetic fields, radiofrequency pulses, and field gradients to form images of the body. Contrast agents based on paramagnetic compounds are commonly used to enhance the signal/noise ratio. More recently, MRI procedures have been developed which make use of novel classes of contrast agents, such as hyperpolarized molecules for high sensitivity metabolic studies, or CEST agents for accurate pH parametric imaging.
Magnetic Resonance Spectroscopy (MRS) can be used to complement MRI in the characterization of tissues. While MRI makes use of water proton signals to create images, MRS uses either proton or heteronuclei signals to determine the relative concentrations of target metabolites.
In microMRI/MRS, the instrumentation is implemented with accessories or with a technical set-up optimized for small animal studies, providing resolution in the mm to µm range.