Correlated Imaging Series: Multimodal Imaging and Omics Analysis to characterize senescent cells


Published November 21, 2022
Technology
Category

On Friday, November 18th at 13:00 CET, Martina Marchetti-Deschmann, TU Wien, delivers a lecture on “Multimodal Imaging and Omics Analysis to characterize senescent cells” as part of the Correlated Imaging Series, brought to you by COMULIS and Euro-BioImaging.

Abstract:
Martina Marchetti-Deschmann introduces the concept of MALDI Mass Spectrometry based imaging (MALDI MSI) in the context of investigations on aging skin. Our skin is constantly exposed to solar radiation, high oxygen levels, and environmental pollutants and lipid oxidation is an already described senescence-associated secretory phenotype (SASP). Previously several oxidized phosphatidylcholines (OxPCs) were characterized in a semi-targeted lipidomic approach. We now went one step further and studied the localization and relative quantity of lipids in a 3D skin model. Our study aims to evaluate the epilipidomic effects via untargeted multimodal imaging focusing on OxPCs. We employed MALDI MSI to generate OxPC distribution maps in the skin model but also in skin biopsies from donors of different age. The synergy of mass spectrometry and high-definition light-microscopy and immunohistology images yield a detailed and comprehensive result for UV-induced alterations. 

Friday, December 17th at 13:00 CET

Join via internet: https://us02web.zoom.us/j/760003029 or via phone:

Meeting ID: 760 003 029 Find your local number: https://zoom.us/u/acj97wMY13


More news from Euro-BioImaging

Euro-BioImaging Map 2025

May 30, 2025

Euro-BioImaging expands!

The Node upgrade process is a process by which existing Euro-BioImaging Nodes can add additional facilities to their Node, expanding the infrastructure by onboarding…

12th Euro-BioImaging Board Meeting

May 27, 2025

Euro-BioImaging Board Meeting in Amsterdam

The 12th Euro-BioImaging Board meeting took place in Amsterdam, from May 13-14, 2025, hosted by our colleagues from NL-BioImaging. It was the occasion for…

May 23, 2025

Imaging for understanding plant disease dynamics

Xylella fastidiosa is a vector-borne gram-negative xylem-limited bacterium native to the Americas, affecting more than 650 plant species, including crops of major economic importance. The bacterial sequence…