Correlated Imaging Series: Multimodal imaging of human retina pathology


Published October 24, 2022
Technology
Category

On Friday, October 28th at 13:00 CEST, Kevin L. Schey, PhD, Department of Biochemistry, Vanderbilt University, delivers a lecture on “Multimodal imaging of human retina pathology,”as part of the Correlated Imaging Series, brought to you by COMULIS and Euro-BioImaging.

Abstract:

Retina deposits form with age and their presence is the highest known risk factor for the development of age-related macular degeneration (AMD); the leading cause of blindness in older adults. Deposits, such as drusen and basal laminar deposits, form below the retinal pigmented epithelium (RPE) whereas deposits, such as subretinal drusenoid deposits (SDD), form above the RPE. The molecular composition of such deposits, which are only partly known, varies depending on their regional and laminar locations. Thus, accurate localization is essential for interpreting imaging mass spectrometry (IMS) results. Furthermore, given the exquisite architecture of the retina, a multimodal imaging approach is required to establish the localization of IMS signals. The general goal of this study is to use multimodal imaging methods including ex vivo OCT, autofluorescence, optical microscopy, and state-of-the-art IMS methods to elucidate the molecular composition of different retinal deposits in aged human tissue. Such information can molecularly inform clinical imaging modalities.

Friday, October 28th, at 13:00 CEST

Join via internet: https://us02web.zoom.us/j/760003029 or via phone:

Meeting ID: 760 003 029 Find your local number: https://zoom.us/u/acj97wMY13

About Kevin Schey: 

Kevin L. Schey, Ph.D, is Professor of Biochemistry, Chemistry, and Ophthalmology & Visual Sciences at Vanderbilt University. He earned his Ph.D. from Purdue University in 1989 and has 30+ years of professional experience in mass spectrometry and analytical chemistry, including all aspects of proteomics analysis and mass spectrometry imaging. His application area of interest is the eye, particularly lens and retina biochemistry. He directs the Core Facility operations of the MSRC.


More news from Euro-BioImaging

image analysis training course

October 2, 2025

Successful Advanced Methods in BioImage Analysis course

BioImage data analysis is a fast-paced field, at the intersection of computer science and other scientific disciplines. BioImage data analysts support user projects from…

Man in front of a microscope

October 1, 2025

Meet Andreas Bodén, Microscopy Innovation Centre at King’s College London

As part of our ongoing series spotlighting the talented scientists working at the Euro-BioImaging Nodes, our Scientific Ambassador Virginia Silió sat down with Andreas…

Group photo at the EU-Australian Health Research Infrastructure Symposium in Prato, 2025.

September 24, 2025

Successful Australian & European Health Research Infrastructures symposium

From September 16-19, 2025, representatives of European and Australian Health Research Infrastructures gathered at the Monash University Prato Centre in Prato, Italy. The Euro-BioImaging…