From prototype to commercialization: Image Scanning Microscopy with SPAD Array Detector – Bridging the Gap between super-resolution and confocal microscopy

At the Special Edition Virtual Pub, “Innovation in Imaging,” we will discuss some of the issues that innovators should be aware of and hear use cases from our network about successful tech transfer and translation from the lab.

When: September 27, 2024, from 13:00-15:30 CEST

Where: Online

At this event, Giuseppe Vicidomini, will present “From prototype to commercialization: Image Scanning Microscopy with SPAD Array Detector - Bridging the Gap between super-resolution and confocal microscopy.” His talk will explore two models of technology transfer, including an academia-industry collaboration and an open science model that allows end-users to contribute to the development process.   

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Abstract

The last decades of fluorescence microscopy developments have been dominated by super-resolution techniques, yet the relatively older method of confocal laser scanning microscopy remains one of the most prevalent in imaging facilities worldwide. Confocal systems persist due to their robustness, ease of use, and versatility. However, the gap between confocal and super-resolution microscopy highlights the need for technologies that combine high resolution with accessibility.

In this context, Giuseppe Vicidomini presents the development and commercialization of Image Scanning Microscopy (ISM) powered by Single-Photon Avalanche Diode (SPAD) array detectors. This system enhances spatial resolution while maintaining the practical advantages of confocal microscopy. This work, in collaboration with Nikon and the Genoa Instruments startup, successfully translated SPAD-based ISM from a research prototype into a commercial platform.

Beyond ISM, the SPAD array detector has given rise to a new paradigm called photon-resolved microscopy, which is still in its early stages. To realise its full potential, the microscopy community needs to explore and refine this approach. For this reason, the transfer of photon-resolved microscopy technology occurs through open-science projects rather than a finalised product, allowing the community to actively participate in its development. This open-access model fosters innovation and creates opportunities for new ideas like ISM to emerge.

These two models of technology transfer not only drive the refinement of techniques like ISM but also bridge the gap between research and practical applications, paving the way for future breakthroughs in both fundamental biology and biomedical research.