Proof of Concept

Euro-BioImaging has launched a Proof-of-Concept study to provide users access to a number of new imaging technologies. We are currently accepting applications to use these technologies as part of the Proof-of-Concept study at different Euro-BioImaging Nodes. We strongly encourage you to apply, and benefit from the help of the experts at our Nodes. Your participation allows us to validate new technologies and allows you to take advantage of the latest breakthroughs in imaging research.

Available technologies

Biological imaging technologies

Lattice lightsheet

Want to see adherent cells with low phototoxicity and photobleaching? What about spheroids and organoids?

Both of these are possible with Lattice Light-sheet imaging, an interesting approach for those studying adherent cells, membrane systems, spheroids and organoids. We spoke to Steven Edwards, at the Advanced Light Microscopy facility at SciLifeLab in Sweden, part of our Swedish NMI Node, to learn more about this technology and what it can be used for in the interview below. Read the news article here.

Random Illumination Microscopy

Are you interested in looking at tissues or other thick samples in high resolution?

Marc Tramier, a group leader at the Institute of Genetics & Development of the University of Rennes/INSERM/CNRS, and scientific director of MRic (Microscopy Rennes Imaging Centre), tells us more about Random Illumination Microscopy (RIM), a fast and easy to use microscopy technique with low phototoxicity. Read the news article here.


Want to see objects that are 5 nanometers apart? Need to track objects moving in live cells with high temporal resolution?

Then why not give MINFLUX a try? We spoke to Christopher Tynan, a staff scientist at Central Laser Facility - Octopus Cluster. His facility, which is part of the Euro-BioImaging UK Node, to learn more. Read the news article here.

Need a light microscopy technique that closes the gap on structural biology?

We spoke to Timo Zimmerman, Head of Light Microscopy applications at the EMBL Imaging Centre, part of Euro-BioImaging’s EMBL Node, to learn more about MINFLUX and what it can be used for. Read the news article here.


Want to look at tumor vs. healthy tissue within a sample?

Laser microdissection enables you to select a material based on its spatial or qualitative traits. We spoke to Natalia Nowak, a biologist at the Laboratory of Imaging Tissue Structure and Function - light microscopy core-facility of Nencki Institute of Experimental Biology in Warsaw, Poland, part of our Polish Advanced Light Microscopy Node, to learn more. Read the news article here.

Expansion Microscopy

Want to look at subcellular structures such as mitochondria, centrioles and microtubules in super-resolution? Only have access to conventional diffraction-limited microscopes?

By physically expanding the sample, expansion microscopy (ExM) can achieve super-resolution images of your immune-stained adherent cells. We spoke to Ana Agostinho and Steven Edwards, at the Advanced Light Microscopy facility at SciLifeLab in Sweden, part of our Swedish NMI Node, to learn more. Read the news article here.

Spatial Transcriptomics

Spatial Transcriptomics is a useful approach for understanding tissue architecture and for understanding the molecular basis of health and disease. The Bioscience Technology Facility at the University of York, part of our UK Node, has experience with this exciting technique and is now accepting applications for spatial transcriptomics projects as part of the Euro-BioImaging Proof-of-Concept study. We spoke with Peter O’Toole, Director of the Bioscience Technology Facility, the University of York, part of our UK Node, to find out more about this approach and what it can be used for. Read the news article here.


Correlative X-ray imaging and electron microscopy (CXEM) is the combination of X-ray imaging and electron microscopy. It is a correlative approach that makes it possible to characterise a sample of interest and locate a structure of interest in a non-destructive way. Nicolas BROUILLY, in charge of the Electron Microscopy Unit of the PICsL imaging facility on the Marseille node of France BioImaging, tells us more about how this approach works and what it can be used for. Read the news article here.

More technologies:

Animal/plant and human imaging

Magnetoencelography (MEG)

Magnetoencephalography (MEG) measures noninvasively minute magnetic fields produced by neuronal activity of the brain. Source modelling is used in MEG to model, quantify, and localize sources contributing to the measured magnetic fields at ms temporal resolution and a few mm spatial resolution. We spoke to Veikko Jousmäki, physicist, senior scientist, Head of Aalto NeuroImaging open-access research infrastructure for human functional neuroimaging at Aalto University, Espoo, Finland, to learn more. Read the news article here.

Plant Phenotyping

Trying to understand optimum growth conditions for small to mid-size crop plants? Studying the impact of drought and other climate factors? Need to perform non-invasive, morphometric and physiological high-throughput phenotyping? 

Jakub Jez, Head of the Vienna BioCenter Core Facilities GmbH - Plant Sciences Facility, part of Austrian BioImaging/CMI Node, explains PHENOPlant, an automated, multi-sensor, high-throughput plant phenotyping platform (PHENOPlant). Read the news article here.

Who should apply?

All scientists, regardless of their affiliation, area of expertise or field of activity can benefit from Euro-BioImaging’s pan-European open access services.

How to apply?

Potential users of these new technologies are encouraged to submit project proposals via our website. To do so, you can log in to access our application platform, choose the technology you want to use and the facility you wish to visit, then submit your proposal. All applications will be processed by the Euro-BioImaging Hub. As usual, users will benefit from advice and guidance by technical experts working at the Nodes, training opportunities, and data management services.

Funding opportunities

Please visit the Funding User Access page of our website for a complete overview.